Vitamin K-Antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype

BACKGROUND: Vitamin K-antagonists (VKA) are treatment of choice and standard care for patients with venous thrombosis and thromboembolic risk. In experimental animal models as well as humans, VKA have been shown to promote medial elastocalcinosis. As vascular calcification is considered an independe...

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Hauptverfasser: Schurgers, Leon J., Joosen, Ivo A., Laufer, Eduard M., Chatrou, Martijn L. L., Herfs, Marjolein, Winkens, Mark H. M., Westenfeld, Ralf, Veulemans, Verena, Krueger, Thilo, Shanahan, Catherine M., Jahnen-Dechent, Willi, Biessen, Erik, Narula, Jagat, Vermeer, Cees, Hofstra, Leonard, Reutelingsperger, Chris P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430691/
https://ncbi.nlm.nih.gov/pubmed/22952653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043229
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