Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR(-/-) Mice on Western Type Diet

OBJECTIVE: To investigate therapeutic effects of annexin A1 (anxA1) on atherogenesis in LDLR(-/-) mice. METHODS: Human recombinant annexin A1 (hr-anxA1) was produced by a prokaryotic expression system, purified and analysed on phosphatidylserine (PS) binding and formyl peptide receptor (FPR) activat...

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Pubblicato in:PLoS One
Autori principali: Kusters, Dennis H. M., Chatrou, Martijn L., Willems, Brecht A. G., De Saint-Hubert, Marijke, Bauwens, Matthias, van der Vorst, Emiel, Bena, Stefania, Biessen, Erik A. L., Perretti, Mauro, Schurgers, Leon J., Reutelingsperger, Chris P. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475013/
https://ncbi.nlm.nih.gov/pubmed/26090792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130484
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