Vitamin K-Antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype

BACKGROUND: Vitamin K-antagonists (VKA) are treatment of choice and standard care for patients with venous thrombosis and thromboembolic risk. In experimental animal models as well as humans, VKA have been shown to promote medial elastocalcinosis. As vascular calcification is considered an independe...

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主要な著者: Schurgers, Leon J., Joosen, Ivo A., Laufer, Eduard M., Chatrou, Martijn L. L., Herfs, Marjolein, Winkens, Mark H. M., Westenfeld, Ralf, Veulemans, Verena, Krueger, Thilo, Shanahan, Catherine M., Jahnen-Dechent, Willi, Biessen, Erik, Narula, Jagat, Vermeer, Cees, Hofstra, Leonard, Reutelingsperger, Chris P.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430691/
https://ncbi.nlm.nih.gov/pubmed/22952653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043229
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