Structures of Human DPP7 Reveal the Molecular Basis of Specific Inhibition and the Architectural Diversity of Proline-Specific Peptidases

Proline-specific dipeptidyl peptidases (DPPs) are emerging targets for drug development. DPP4 inhibitors are approved in many countries, and other dipeptidyl peptidases are often referred to as DPP4 activity- and/or structure-homologues (DASH). Members of the DASH family have overlapping substrate s...

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Autores principales: Bezerra, Gustavo Arruda, Dobrovetsky, Elena, Dong, Aiping, Seitova, Almagul, Crombett, Lissete, Shewchuk, Lisa M., Hassell, Annie M., Sweitzer, Sharon M., Sweitzer, Thomas D., McDevitt, Patrick J., Johanson, Kyung O., Kennedy-Wilson, Karen M., Cossar, Doug, Bochkarev, Alexey, Gruber, Karl, Dhe-Paganon, Sirano
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430648/
https://ncbi.nlm.nih.gov/pubmed/22952628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043019
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