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Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III

Opioid peptides are involved in various essential physiological processes, most notably nociception. Dipeptidyl peptidase III (DPP III) is one of the most important enkephalin-degrading enzymes associated with the mammalian pain modulatory system. Here we describe the X-ray structures of human DPP I...

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Detalhes bibliográficos
Main Authors: Bezerra, Gustavo A., Dobrovetsky, Elena, Viertlmayr, Roland, Dong, Aiping, Binter, Alexandra, Abramić, Marija, Macheroux, Peter, Dhe-Paganon, Sirano, Gruber, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340026/
https://ncbi.nlm.nih.gov/pubmed/22493238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118005109
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