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Barrier Crossing in Dihydrofolate Reductasedoes not involve a rate-promoting vibration
We have studied atomic motions during the chemical reaction catalyzed by the enzyme dihydrofolate reductase of Escherichia coli (EcDHFR), an important enzyme for nucleic acid synthesis. In our earlier work on the enzymes human lactate dehydrogenase and purine nucleoside phosphorylase, we had identif...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3430383/ https://ncbi.nlm.nih.gov/pubmed/22942460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00268976.2012.655337 |
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