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Targeting a Rate-Promoting Vibration with an Allosteric Mediator in Lactate Dehydrogenase
[Image: see text] We present a new type of allosteric modulation in which a molecule bound outside the active site modifies the chemistry of an enzymatic reaction through rapid protein dynamics. As a test case for this type of allostery, we chose an enzyme with a well-characterized rate-promoting vi...
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| Publicado no: | J Phys Chem Lett |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2016
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4939807/ https://ncbi.nlm.nih.gov/pubmed/27327209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpclett.6b01209 |
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