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Barrier Crossing in Dihydrofolate Reductasedoes not involve a rate-promoting vibration

We have studied atomic motions during the chemical reaction catalyzed by the enzyme dihydrofolate reductase of Escherichia coli (EcDHFR), an important enzyme for nucleic acid synthesis. In our earlier work on the enzymes human lactate dehydrogenase and purine nucleoside phosphorylase, we had identif...

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Autori principali: Dametto, Mariangela, Antoniou, Dimitri, Schwartz, Steven D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430383/
https://ncbi.nlm.nih.gov/pubmed/22942460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00268976.2012.655337
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