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AU-Rich-Element-Mediated Upregulation of Translation by FXR1 and Argonaute 2

AU-rich elements (AREs), present in mRNA 3′-UTRs, are potent posttranscriptional regulatory signals that can rapidly effect changes in mRNA stability and translation, thereby dramatically altering gene expression with clinical and developmental consequences. In human cell lines, the TNFα ARE enhance...

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Detalhes bibliográficos
Main Authors: Vasudevan, Shobha, Steitz, Joan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430382/
https://ncbi.nlm.nih.gov/pubmed/17382880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.01.038
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