Conservation of a Triple-Helix Forming RNA Stability Element in Noncoding and Genomic RNAs of Diverse Viruses

Abundant expression of the long noncoding (lnc) PAN (polyadenylated nuclear) RNA by the human oncogenic gammaherpesvirus KSHV depends on a cis-element called the ENE. The ENE upregulates PAN RNA by inhibiting its rapid nuclear decay through triple-helix formation with the poly(A) tail. Using structu...

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Main Authors: Tycowski, Kazimierz T., Shu, Mei-Di, Borah, Sumit, Shi, Mary, Steitz, Joan A.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430378/
https://ncbi.nlm.nih.gov/pubmed/22840393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.05.020
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