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Key role of the positive feedback between PGE(2) and COX2 in the biology of myeloid-derived suppressor cells
PGE(2) is the key factor needed for MDSCs development, accumulation and functional stability. PGE(2) initiates an EP2/EP4-mediated positive feedback between COX2 and PGE(2) in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functio...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Landes Bioscience
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3429587/ https://ncbi.nlm.nih.gov/pubmed/22934275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.19681 |
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