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PD-1 and BTLA and CD8(+) T-cell “exhaustion” in cancer: “Exercising” an alternative viewpoint

The elevated expression of PD-1, BTLA, and other co-inhibitory molecules on T cells from cancer patients has become an accepted signature for a state called T-cell “exhaustion” that has emerged almost as dogma in the field. However, here we propose that in some cases this “exhausted” T-cell phenotyp...

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Bibliographic Details
Main Authors: Haymaker, Cara, Wu, Richard, Bernatchez, Chantale, Radvanyi, Laszlo
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429577/
https://ncbi.nlm.nih.gov/pubmed/22934265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.20823
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