Multifaceted role of BTLA in the control of CD8(+) T cell fate after antigen encounter

PURPOSE: Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes (TIL) has shown an overall clinical response rate 40–50% in metastatic melanoma patients. BTLA (B-and-T lymphocyte attenuator) expression on transferred CD8(+) TIL was associated with better clinical outcome. The suppre...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Ritthipichai, Krit, Haymaker, Cara L., Martinez, Melisa, Aschenbrenner, Andrew, Yi, Xiaohui, Zhang, Minying, Kale, Charuta, Vence, Luis M., Roszik, Jason, Hailemichael, Yared, Overwijk, Willem W., Varadarajan, Navin, Nurieva, Roza, Radvanyi, Laszlo G., Hwu, Patrick, Bernatchez, Chantale
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748156/
https://ncbi.nlm.nih.gov/pubmed/28754817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1217
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