Multifaceted role of BTLA in the control of CD8(+) T cell fate after antigen encounter

PURPOSE: Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes (TIL) has shown an overall clinical response rate 40–50% in metastatic melanoma patients. BTLA (B-and-T lymphocyte attenuator) expression on transferred CD8(+) TIL was associated with better clinical outcome. The suppre...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Ritthipichai, Krit, Haymaker, Cara L., Martinez, Melisa, Aschenbrenner, Andrew, Yi, Xiaohui, Zhang, Minying, Kale, Charuta, Vence, Luis M., Roszik, Jason, Hailemichael, Yared, Overwijk, Willem W., Varadarajan, Navin, Nurieva, Roza, Radvanyi, Laszlo G., Hwu, Patrick, Bernatchez, Chantale
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748156/
https://ncbi.nlm.nih.gov/pubmed/28754817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1217
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