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Crystal Structures of Three Classes of Non-Steroidal Anti-Inflammatory Drugs in Complex with Aldo-Keto Reductase 1C3

Aldo-keto reductase 1C3 (AKR1C3) catalyses the NADPH dependent reduction of carbonyl groups in a number of important steroid and prostanoid molecules. The enzyme is also over-expressed in prostate and breast cancer and its expression is correlated with the aggressiveness of the disease. The steroid...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Flanagan, Jack U., Yosaatmadja, Yuliana, Teague, Rebecca M., Chai, Matilda Z. L., Turnbull, Andrew P., Squire, Christopher J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429426/
https://ncbi.nlm.nih.gov/pubmed/22937138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043965
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