Transcriptome-wide Regulation of Pre-mRNA Splicing and mRNA Localization by Muscleblind Proteins

The Muscleblind-like (Mbnl) family of RNA binding proteins plays important roles in muscle and eye development and in Myotonic Dystrophy (DM), where expanded CUG or CCUG repeats functionally deplete Mbnl proteins. We identified transcriptome-wide functional and biophysical targets of Mbnl proteins i...

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Main Authors: Wang, Eric T., Cody, Neal A. L., Jog, Sonali, Biancolella, Michela, Wang, Thomas T., Treacy, Daniel J., Luo, Shujun, Schroth, Gary P., Housman, David E., Reddy, Sita, Lécuyer, Eric, Burge, Christopher B.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428802/
https://ncbi.nlm.nih.gov/pubmed/22901804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.06.041
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