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Structural Transitions of Transmembrane Helix 6 in the Formation of Metarhodopsin I

Absorption of light by the visual pigment rhodopsin triggers a rapid cis-trans photoisomerization of its retinal chromophore and a series of conformational changes in both the retinal and protein. The largest structural change is an outward tilt of transmembrane helix H6 that increases the separatio...

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Autors principals: Eilers, Markus, Goncalves, Joseph A., Ahuja, Shivani, Kirkup, Colleen, Hirshfeld, Amiram, Simmerling, Carlos, Reeves, Philip J., Sheves, Mordechai, Smith, Steven O.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428503/
https://ncbi.nlm.nih.gov/pubmed/22564141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp3019183
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