A DNA-Based Candidate HIV Vaccine Delivered via In Vivo Electroporation Induces CD4 Responses toward the α4β7-Binding V2 Loop of HIV gp120 in Healthy Volunteers

Administration of a clade C/B′ candidate HIV-1 DNA vaccine, ADVAX, by in vivo electroporation (EP) was safe and more immunogenic than intramuscular administration without EP. The breadth and specificity of T-cell responses to full-length Env were mapped. Responses to multiple Env regions were induce...

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Bibliografische gegevens
Hoofdauteurs: Kopycinski, Jakub, Cheeseman, Hannah, Ashraf, Ambreen, Gill, Dilbinder, Hayes, Peter, Hannaman, Drew, Gilmour, Jill, Cox, Josephine H., Vasan, Sandhya
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2012
Onderwerpen:
Vaccines
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428404/
https://ncbi.nlm.nih.gov/pubmed/22837097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00327-12
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