In Vivo Electroporation Enhances the Immunogenicity of an HIV-1 DNA Vaccine Candidate in Healthy Volunteers

BACKGROUND: DNA-based vaccines have been safe but weakly immunogenic in humans to date. METHODS AND FINDINGS: We sought to determine the safety, tolerability, and immunogenicity of ADVAX, a multigenic HIV-1 DNA vaccine candidate, injected intramuscularly by in vivo electroporation (EP) in a Phase-1,...

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Bibliografske podrobnosti
Main Authors: Vasan, Sandhya, Hurley, Arlene, Schlesinger, Sarah J., Hannaman, Drew, Gardiner, David F., Dugin, Daniel P., Boente-Carrera, Mar, Vittorino, Roselle, Caskey, Marina, Andersen, Johanne, Huang, Yaoxing, Cox, Josephine H., Tarragona-Fiol, Tony, Gill, Dilbinder K., Cheeseman, Hannah, Clark, Lorna, Dally, Len, Smith, Carol, Schmidt, Claudia, Park, Harriet H., Kopycinski, Jakub T., Gilmour, Jill, Fast, Patricia, Bernard, Robert, Ho, David D.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095594/
https://ncbi.nlm.nih.gov/pubmed/21603651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019252
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