Phase 1 Safety and Immunogenicity Evaluation of ADVAX, a Multigenic, DNA-Based Clade C/B' HIV-1 Candidate Vaccine

BACKGROUND: We conducted a Phase I dose escalation trial of ADVAX, a DNA-based candidate HIV-1 vaccine expressing Clade C/B' env, gag, pol, nef, and tat genes. Sequences were derived from a prevalent circulating recombinant form in Yunnan, China, an area of high HIV-1 incidence. The objective w...

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Detalhes bibliográficos
Main Authors: Vasan, Sandhya, Schlesinger, Sarah J., Huang, Yaoxing, Hurley, Arlene, Lombardo, Angela, Chen, Zhiwei, Than, Soe, Adesanya, Phumla, Bunce, Catherine, Boaz, Mark, Boyle, Rosanne, Sayeed, Eddy, Clark, Lorna, Dugin, Daniel, Schmidt, Claudia, Song, Yang, Seamons, Laura, Dally, Len, Ho, Martin, Smith, Carol, Markowitz, Martin, Cox, Josephine, Gill, Dilbinder K., Gilmour, Jill, Keefer, Michael C., Fast, Patricia, Ho, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799527/
https://ncbi.nlm.nih.gov/pubmed/20111582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008617
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