A Comparison of EGFR Mutation Testing Methods in Lung Carcinoma: Direct Sequencing, Real-time PCR and Immunohistochemistry

The objective of this study is to compare two EGFR testing methodologies (a commercial real-time PCR kit and a specific EGFR mutant immunohistochemistry), with direct sequencing and to investigate the limit of detection (LOD) of both PCR-based methods. We identified EGFR mutations in 21 (16%) of the...

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Detalhes bibliográficos
Main Authors: Angulo, Bárbara, Conde, Esther, Suárez-Gauthier, Ana, Plaza, Carlos, Martínez, Rebeca, Redondo, Pilar, Izquierdo, Elisa, Rubio-Viqueira, Belén, Paz-Ares, Luis, Hidalgo, Manuel, López-Ríos, Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428292/
https://ncbi.nlm.nih.gov/pubmed/22952784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043842
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