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Aneuploidy as a mechanism for stress-induced liver adaptation

Over half of the mature hepatocytes in mice and humans are aneuploid and yet retain full ability to undergo mitosis. This observation has raised the question of whether this unusual somatic genetic variation evolved as an adaptive mechanism in response to hepatic injury. According to this model, hep...

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Détails bibliographiques
Auteurs principaux: Duncan, Andrew W., Hanlon Newell, Amy E., Bi, Weimin, Finegold, Milton J., Olson, Susan B., Beaudet, Arthur L., Grompe, Markus
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428097/
https://ncbi.nlm.nih.gov/pubmed/22863619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64026
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