Aneuploidy as a mechanism for stress-induced liver adaptation

Over half of the mature hepatocytes in mice and humans are aneuploid and yet retain full ability to undergo mitosis. This observation has raised the question of whether this unusual somatic genetic variation evolved as an adaptive mechanism in response to hepatic injury. According to this model, hep...

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Detaylı Bibliyografya
Asıl Yazarlar: Duncan, Andrew W., Hanlon Newell, Amy E., Bi, Weimin, Finegold, Milton J., Olson, Susan B., Beaudet, Arthur L., Grompe, Markus
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428097/
https://ncbi.nlm.nih.gov/pubmed/22863619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64026
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