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Aneuploidy as a mechanism for stress-induced liver adaptation
Over half of the mature hepatocytes in mice and humans are aneuploid and yet retain full ability to undergo mitosis. This observation has raised the question of whether this unusual somatic genetic variation evolved as an adaptive mechanism in response to hepatic injury. According to this model, hep...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3428097/ https://ncbi.nlm.nih.gov/pubmed/22863619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64026 |
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