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Pregabalin Suppresses Spinal Neuronal Hyperexcitability and Visceral Hypersensitivity in the Absence of Peripheral Pathophysiology

BACKGROUND: Opioid induced hyperalgesia is recognised in the laboratory and the clinic, generating central hyperexcitability in the absence of peripheral pathology. We investigated pregabalin, indicated for neuropathic pain, and ondansetron, a drug that disrupts descending serotonergic processing in...

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Auteurs principaux: Bannister, Kirsty, Sikandar, Shafaq, Bauer, Claudia S., Dolphin, Annette C., Porreca, Frank, Dickenson, Anthony H.
Format: Artigo
Langue:Inglês
Publié: 2011
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427727/
https://ncbi.nlm.nih.gov/pubmed/21602662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e31821f6545
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