Effect of SkM1 Sodium Channels Delivered Via a Cell Platform on Cardiac Conduction and Arrhythmia Induction

BACKGROUND: In depolarized myocardial infarct epicardial border zones (EBZ), the cardiac sodium channel is largely inactivated, contributing to slow conduction and reentry. We have demonstrated that adenoviral delivery of the skeletal muscle sodium channel SkM1 to EBZ normalizes conduction and reduc...

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Main Authors: Boink, Gerard J.J., Lu, Jia, Driessen, Helen E., Duan, Lian, Sosunov, Eugene A., Anyukhovsky, Evgeny P., Shlapakova, Iryna N., Lau, David H., Rosen, Tove S., Danilo, Peter, Jia, Zhiheng, Ozgen, Nazira, Bobkov, Yevgeniy, Guo, Yuanjian, Brink, Peter R., Kryukova, Yelena, Robinson, Richard B., Entcheva, Emilia, Cohen, Ira S., Rosen, Michael R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427660/
https://ncbi.nlm.nih.gov/pubmed/22722661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.111.969907
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