Epicardial border zone overexpression of skeletal muscle sodium channel, SkM1, normalizes activation, preserves conduction and suppresses ventricular arrhythmia: an in silico, in vivo, in vitro study

BACKGROUND: In depolarized myocardial infarct epicardial border zones (EBZ), the cardiac sodium channel (SCN5A) is largely inactivated, contributing to low action potential upstroke velocity (V(max)), slow conduction and reentry. We hypothesized a fast inward current such as the skeletal muscle sodi...

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Detalhes bibliográficos
Main Authors: Lau, David H., Clausen, Chris, Sosunov, Eugene A., Shlapakova, Iryna N., Anyukhovsky, Evgeny P., Danilo, Peter, Rosen, Tove S., Kelly, Caitlin, Duffy, Heather S., Szabolcs, Matthias J., Chen, Ming, Robinson, Richard B., Lu, Jia, Kumari, Sinhu, Cohen, Ira S., Rosen, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731654/
https://ncbi.nlm.nih.gov/pubmed/19103989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.809301
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