Expression of skeletal muscle sodium channel (Nav1.4) or connexin32 prevents reperfusion arrhythmias in murine heart

AIMS: Acute myocardial ischaemia induces a decrease in resting membrane potential [which leads to reduction of action potential (AP) V(max)] and intracellular acidification (which closes gap junctions). Both contribute to conduction slowing. We hypothesized that ventricular expression of the skeleta...

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Detalhes bibliográficos
Main Authors: Anyukhovsky, Evgeny P., Sosunov, Eugene A., Kryukova, Yelena N., Prestia, Kevin, Ozgen, Nazira, Rivaud, Mathilde, Cohen, Ira S., Robinson, Richard B., Rosen, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002874/
https://ncbi.nlm.nih.gov/pubmed/20823275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq284
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