Deleting the accessory subunit KChIP2 results in loss of I(to,f) and increased I(K,slow) that maintains normal action potential configuration

BACKGROUND: Four voltage-gated potassium currents: I(to,f) (K(V)4.2), I(to,s) (K(V)1.4), I(K,slow) (K(V)1.5+K(V)2.1), and I(SS) (TASK1) govern murine ventricular repolarization. Although the accessory subunit, KChIP2, influences I(to,f) expression, in preliminary experiments we found that action pot...

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Hlavní autoři: Thomsen, Morten B., Sosunov, Eugene A., Anyukhovsky, Evgeny P., Özgen, Nazira, Boyden, Penelope A., Rosen, Michael R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731656/
https://ncbi.nlm.nih.gov/pubmed/19251214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2008.11.023
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