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Microsatellite instability in colorectal cancer—the stable evidence
Microsatellite instability (MSI) is the molecular fingerprint of a deficient mismatch repair system. Approximately 15% of colorectal cancers (CRC) display MSI owing to either epigenetic silencing of MLH1 or a germline mutation in one of the mismatch repair genes MLH1, MSH2, MSH6 or PMS2. Methods to...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3427139/ https://ncbi.nlm.nih.gov/pubmed/20142816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrclinonc.2009.237 |
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