RAS/ERK inhibition rescues fate-specification defects of Nf1-deficient neural progenitors and brain abnormalities

Germline mutations in the RAS/ERK signaling pathway underlie several related developmental disorders collectively termed neuro-cardio-facial-cutaneous (NCFC) syndromes. Patients with these disorders manifest varying degrees of cognitive impairment, but the developmental basis of their brain abnormal...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Wang, Yuan, Kim, Edward, Wang, Xiaojing, Novitch, Bennett G., Yoshikawa, Kazuaki, Chang, Long-Sheng, Zhu, Yuan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427010/
https://ncbi.nlm.nih.gov/pubmed/22901811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.06.034
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares