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RAS/ERK inhibition rescues fate-specification defects of Nf1-deficient neural progenitors and brain abnormalities
Germline mutations in the RAS/ERK signaling pathway underlie several related developmental disorders collectively termed neuro-cardio-facial-cutaneous (NCFC) syndromes. Patients with these disorders manifest varying degrees of cognitive impairment, but the developmental basis of their brain abnormal...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3427010/ https://ncbi.nlm.nih.gov/pubmed/22901811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.06.034 |
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