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Direct and Differential Suppression of Myeloid-derived Suppressor Cell Subsets by Sunitinib is Compartmentally Constrained

The anti-angiogenic drug sunitinib is a receptor tyrosine-kinase inhibitor with significant, yet not curative, therapeutic impacts in metastatic renal cell carcinoma (mRCC). Sunitinib is also an immunomodulator, potently reversing myeloid-derived suppressor cell (MDSC) accumulation and T-cell inhibi...

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Autors principals: Ko, Jennifer S, Rayman, Patricia, Ireland, Joanna, Swaidani, Shadi, Li, Geqiang, Bunting, Kevin D, Rini, Brian, Finke, James H, Cohen, Peter A
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426924/
https://ncbi.nlm.nih.gov/pubmed/20406969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3278
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