Synthesis and Evaluation of Substituted Chroman-4-one and Chromone Derivatives as Sirtuin 2-Selective Inhibitors

[Image: see text] A series of substituted chromone/chroman-4-one derivatives has been synthesized and evaluated as novel inhibitors of SIRT2, an enzyme involved in aging-related diseases, e.g., neurodegenerative disorders. The analogues were efficiently synthesized in a one-step procedure including...

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Main Authors: Fridén-Saxin, Maria, Seifert, Tina, Landergren, Marie Rydén, Suuronen, Tiina, Lahtela-Kakkonen, Maija, Jarho, Elina M., Luthman, Kristina
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2012
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426190/
https://ncbi.nlm.nih.gov/pubmed/22746324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3005288
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