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Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production

Insulin-like growth factors (IGFs) are critical for development and growth of skeletal muscles, but because several tissues produce IGFs, it is not clear which source is necessary or sufficient for muscle growth. Because it is critical for production of both IGF-I and IGF-II, we ablated glucose-regu...

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Detalhes bibliográficos
Main Authors: Barton, Elisabeth R., Park, SooHyun, James, Jose K., Makarewich, Catherine A., Philippou, Anastassios, Eletto, Davide, Lei, Hanqin, Brisson, Becky, Ostrovsky, Olga, Li, Zihai, Argon, Yair
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425820/
https://ncbi.nlm.nih.gov/pubmed/22649033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-203026
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