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Impaired propulsive motility in the distal but not proximal colon of BK channel β1-subunit knockout mice

BACKGROUND: Large conductance Ca(2+)-activated K(+) (BK) channels regulate smooth muscle tone. The BK channel β1-subunit increases Ca(2+) sensitivity of the α-subunit in smooth muscle. We studied β1-subunit knockout (KO) mice to determine if gastrointestinal (GI) motility was altered. METHODS: Colon...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: France, Marion, Bhattarai, Yogesh, Galligan, James J., Xu, Hui
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425659/
https://ncbi.nlm.nih.gov/pubmed/22830588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2982.2012.01981.x
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