Soluble α-Synuclein Is a Novel Modulator of Alzheimer's Disease Pathophysiology

Recent evidence has emphasized soluble species of amyloid-β (Aβ) and tau as pathogenic effectors in Alzheimer's disease (AD). Despite the fact that Aβ, tau, and α-synuclein (αSyn) can promote each other's aggregation, the potential contribution of soluble αSyn to AD pathogenesis is unknown...

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Autors principals: Larson, Megan E., Sherman, Mathew A., Greimel, Susan, Kuskowski, Michael, Schneider, Julie A., Bennett, David A., Lesné, Sylvain E.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425439/
https://ncbi.nlm.nih.gov/pubmed/22836259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0581-12.2012
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