Gene Expression Patterns in Mismatch Repair-Deficient Colorectal Cancers Highlight the Potential Therapeutic Role of Inhibitors of the PI3K-AKT-mTOR pathway

PURPOSE: High-frequency microsatellite instable (MSI-H) tumors account for roughly 15% of colorectal cancers (CRC). Therapeutic decisions for CRC are empirically based and currently do not emphasize molecular subclassification despite of the increasing collection of gene expression information. Our...

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Auteurs principaux: Vilar, Eduardo, Mukherjee, Bhramar, Kuick, Rork, Raskin, Leon, Misek, David E., Taylor, Jeremy MG., Giordano, Thomas J., Hanash, Samir M., Fearon, Eric R., Rennert, Gad, Gruber, Stephen B.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425357/
https://ncbi.nlm.nih.gov/pubmed/19351759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2432
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