EGF and HB-EGF enhance the proliferation of programmable cells of monocytic origin (PCMO) through activation of MEK/ERK signaling and improve differentiation of PCMO-derived hepatocyte-like cells

BACKGROUND: Hepatocyte-like cells (NeoHepatocytes) generated from a peripheral blood monocyte-derived stem cell-like cell (the PCMO) are a promising alternative for primary hepatocytes in cell transplantation studies to cure liver diseases. However, to be therapeutically effective NeoHepatocytes are...

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Detalhes bibliográficos
Main Authors: Hyder, Ayman, Ehnert, Sabrina, Hinz, Hebke, Nüssler, Andreas K, Fändrich, Fred, Ungefroren, Hendrik
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425323/
https://ncbi.nlm.nih.gov/pubmed/22873932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-10-23
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