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Evolutionary Meta-Analysis of Association Studies Reveals Ancient Constraints Affecting Disease Marker Discovery

Genome-wide disease association studies contrast genetic variation between disease cohorts and healthy populations to discover single nucleotide polymorphisms (SNPs) and other genetic markers revealing underlying genetic architectures of human diseases. Despite scores of efforts over the past decade...

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Detalhes bibliográficos
Main Authors: Dudley, Joel T., Chen, Rong, Sanderford, Maxwell, Butte, Atul J., Kumar, Sudhir
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424407/
https://ncbi.nlm.nih.gov/pubmed/22389448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mss079
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