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Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage

Lymphatic vessels transport interstitial fluid, soluble antigen, and immune cells from peripheral tissues to lymph nodes (LNs), yet the contribution of peripheral lymphatic drainage to adaptive immunity remains poorly understood. We examined immune responses to dermal vaccination and contact hyperse...

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Detalhes bibliográficos
Main Authors: Thomas, Susan N., Rutkowski, Joseph M., Pasquier, Miriella, Kuan, Emma L., Alitalo, Kari, Randolph, Gwendalyn J., Swartz, Melody A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424306/
https://ncbi.nlm.nih.gov/pubmed/22844119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103545
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