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Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung

Chitin exposure in the lung induces eosinophilia and alternative activation of macrophages, and is correlated with allergic airway disease. However, the mechanism underlying chitin-induced polarization of macrophages is poorly understood. Here, we show that chitin induces alternative activation of m...

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Detalhes bibliográficos
Main Authors: Roy, René M., Wüthrich, Marcel, Klein, Bruce S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424300/
https://ncbi.nlm.nih.gov/pubmed/22851704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200689
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