Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement

BACKGROUND: Dengue viruses (DENV) are the most important arboviruses of humans and cause significant disease. Infection with DENV elicits antibody responses to the envelope glycoprotein, predominantly against immunodominant, cross-reactive, weakly-neutralizing epitopes. These weakly-neutralizing ant...

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Autores principales: Hughes, Holly R, Crill, Wayne D, Chang, Gwong-Jen J
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424142/
https://ncbi.nlm.nih.gov/pubmed/22709350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-9-115
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