Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5′-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists

Novel analogs of the P2 receptor antagonist pyridoxal-5′-phosphate-6-phenylazo-2′,4′-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the inclusion of phosphonates, demonstrating that a pho...

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Autori principali: Kim, Yong-Chul, Camaioni, Emidio, Ziganshin, Airat U., Ji, Xiao-duo, King, Brian F., Wildman, Scott S., Rychkov, Alexei, Yoburn, Joshua, Kim, Heaok, Mohanram, Arvind, Harden, T. Kendall, Boyer, José L., Burnstock, Geoffrey, Jacobson, Kenneth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424000/
https://ncbi.nlm.nih.gov/pubmed/22922976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/(SICI)1098-2299(199810)45:2<52::AID-DDR2>3.0.CO;2-V
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