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Heme Oxygenase Gene Targeting to Adipocyte Attenuates Adiposity and Vascular Dysfunction in Mice Fed a High Fat Diet

We examined the hypothesis that adipocyte dysfunction in mice fed a high fat (HF) diet can be prevented by lentiviral-mediated and adipocyte specific-targeting delivery of the human heme oxygenase-1 (aP2-HO-1). A bolus intracardial injection of aP2-HO-1 resulted in expression of human HO-1 for up to...

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Detalhes bibliográficos
Main Authors: Cao, Jian, Peterson, Stephen J., Sodhi, Komal, Vanella, Luca, Barbagallo, Ignazio, Rodella, Luigi F., Schwartzman, Michal L., Abraham, Nader G., Kappas, Attallah
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423899/
https://ncbi.nlm.nih.gov/pubmed/22753217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.112.193805
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