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Organotypic liver culture models: Meeting current challenges in toxicity testing

Prediction of chemical-induced hepatotoxicity in humans from in vitro data continues to be a significant challenge for the pharmaceutical and chemical industries. Generally, conventional in vitro hepatic model systems (i.e. 2-D static monocultures of primary or immortalized hepatocytes) are limited...

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Bibliographic Details
Main Authors: LeCluyse, Edward L., Witek, Rafal P., Andersen, Melvin E., Powers, Mark J.
Format: Artigo
Language:Inglês
Published: Informa Healthcare 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423873/
https://ncbi.nlm.nih.gov/pubmed/22582993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10408444.2012.682115
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