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CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease
The chemokine CCL3/MIP-1α is a risk factor in the outcome of multiple myeloma (MM), particularly in the development of osteolytic bone disease. This chemokine, highly overexpressed by MM cells, can signal mainly through 2 receptors, CCR1 and CCR5, only 1 of which (CCR1) is responsive to CCL3 in huma...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3423783/ https://ncbi.nlm.nih.gov/pubmed/22618707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-384784 |
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