Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo

There is increasing evidence to suggest that the Wnt signaling pathway plays a critical role in the pathogenesis of myeloma bone disease. In the present study, we determined whether increasing Wnt signaling within the bone marrow microenvironment in myeloma counteracts development of osteolytic bone...

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Hlavní autoři: Edwards, Claire M., Edwards, James R., Lwin, Seint T., Esparza, Javier, Oyajobi, Babatunde O., McCluskey, Brandon, Munoz, Steven, Grubbs, Barry, Mundy, Gregory R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254537/
https://ncbi.nlm.nih.gov/pubmed/18094333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-077685
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