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Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo

There is increasing evidence to suggest that the Wnt signaling pathway plays a critical role in the pathogenesis of myeloma bone disease. In the present study, we determined whether increasing Wnt signaling within the bone marrow microenvironment in myeloma counteracts development of osteolytic bone...

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Detalles Bibliográficos
Main Authors: Edwards, Claire M., Edwards, James R., Lwin, Seint T., Esparza, Javier, Oyajobi, Babatunde O., McCluskey, Brandon, Munoz, Steven, Grubbs, Barry, Mundy, Gregory R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254537/
https://ncbi.nlm.nih.gov/pubmed/18094333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-077685
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