Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer

Cancer immune evasion is an emerging hallmark of disease progression. We have demonstrated previously that impaired actin polymerization at the T-cell immunologic synapse is a global immune dysfunction in chronic lymphocytic leukemia (CLL). Direct contact with tumor cells induces defective actin pol...

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Detalhes bibliográficos
Main Authors: Ramsay, Alan G., Clear, Andrew J., Fatah, Rewas, Gribben, John G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423779/
https://ncbi.nlm.nih.gov/pubmed/22547582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-411678
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