Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug

Cancer is associated with immune deficiency, but the biologic basis of this is poorly defined. Here we demonstrate that impaired actin polymerization results in CD4(+) and CD8(+) T cells from patients with chronic lymphocytic leukemia (CLL) exhibiting defective immunological synapse formation with A...

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Detalhes bibliográficos
Main Authors: Ramsay, Alan G., Johnson, Amy J., Lee, Abigail M., Gorgün, Güllü, Le Dieu, Rifca, Blum, William, Byrd, John C., Gribben, John G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423865/
https://ncbi.nlm.nih.gov/pubmed/18551193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35017
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