Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug

Cancer is associated with immune deficiency, but the biologic basis of this is poorly defined. Here we demonstrate that impaired actin polymerization results in CD4(+) and CD8(+) T cells from patients with chronic lymphocytic leukemia (CLL) exhibiting defective immunological synapse formation with A...

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Bibliografski detalji
Glavni autori: Ramsay, Alan G., Johnson, Amy J., Lee, Abigail M., Gorgün, Güllü, Le Dieu, Rifca, Blum, William, Byrd, John C., Gribben, John G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2008
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423865/
https://ncbi.nlm.nih.gov/pubmed/18551193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35017
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