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Development of a highly selective c-Src kinase inhibitor

Generating highly selective probes to interrogate protein kinase function in biological studies remains a challenge and new strategies are required. Herein, we describe the development of the first highly selective and cell permeable inhibitor of c-Src, a key signaling kinase in cancer. Our strategy...

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Bibliographic Details
Main Authors: Brandvold, Kristoffer R., Steffey, Michael E., Fox, Christel C., Soellner, Matthew B.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423592/
https://ncbi.nlm.nih.gov/pubmed/22594480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300172e
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